What is a lethal dose of THC?

What is a lethal dose of THC?

We are searching data for your request:

Forums and discussions:
Manuals and reference books:
Data from registers:
Wait the end of the search in all databases.
Upon completion, a link will appear to access the found materials.

With the oil form of THC being stronger then ever. What would happen if one was to take a stomach full of THC oil?

According to the abstract from this paper, the intragastric LD50 of $Delta^9THC$ (tetrahydrocannabinol) in sesame oil using Fischer rats was 1270 mg/kg. Assuming rats and humans are identical (they're not), for an average-sized adult human weighing 70 kg (~155 lb.), the median lethal dose would be 88.9 grams, or about 3.1 oz.

Keep in mind that's 3.1 oz. of pure THC. That's a lot of weed.

What is a lethal dose of THC? - Biology

There has never been a documented human fatality solely from overdosing on tetrahydrocannabinol or cannabis in its natural form. However, numerous reports have suggested an association of cannabis smoking with an increased risk of myocardial infarction. Information about the toxicity of THC is primarily based on results from animal studies. The toxicity depends on the route of administration and the laboratory animal.

The estimated lethal dose of intravenous dronabinol (also known as Marinol ) is 30 mg/kg, meaning lethality is unlikely. The typical dosage administered is two 2.5 mg capsules daily for an 80 kg man (

170 lb) to die from a THC overdose, this would translate to 960 capsules infused intravenously to achieve this high a dose. Non-fatal overdoses have occurred: "Significant CNS symptoms in antiemetic studies followed oral doses of 0.4 mg/kg (28 mg/70 kg) of dronabinol capsules."

Its status as an illegal drug in most countries can make research difficult for instance in the United States where the National Institute on Drug Abuse was the only legal source of cannabis for researchers until it recently became legalized in Colorado and Washington.

What Would Theoretically Be A Lethal Dose Of Weed?

Scientists have determined how much of every drug, including recreational drugs, would have to be consumed in order to cause death the way they explain it, they calculate the potential for short-term fatal toxicity. The results are expressed in something called the LD-50, representing a lethal dose for 50% of the test subjects. (Remember, these tests are done on animals, so the results have to be taken with a grain of salt. No, not bath salt.)

Without getting into confusing numbers, the findings show that a potentially lethal dose of heroin or GHB is actually a lot lower than the amount you’d need to get high. However, you’d have to take ten or twenty times the “effective dose” of alcohol, coke or ecstasy to have a 50% chance of death, according to these animal studies for mescaline and roofies, it would require twenty to eighty times the “effective dose” to have a 50% chance of dying.

What about pot? The number is so low that it can’t be measured. When pressed, scientists who calculate LD-50s guess that risking a 50% chance of a deadly overdose would require consuming 100 to 1000 times the amount it would take to get baked. (Our term, not theirs. They use more scientific language.)

Other and more recent ways to measure the potentially deadly effects of a drug involve complicated formulas that include the LD-50. But the end result of the calculations is something called the “therapeutic index,” and initial research on the “TI” shows that the LD-50 numbers are actually quite low.

Marijuana is said to have a therapeutic index of 40,000 to 1 (by comparison, morphine’s TI is 70:1). Here’s what that means: you’d have to consume 40,000 times the “effective” dose of weed before running a significant risk of death. Put another way, you’d have to smoke somewhere between 25,000 and 40,000 joints – or consume 1500 pounds of pot – in 15 minutes. If you want to put that into even greater perspective, the equivalent risk numbers are 1.2 grams of coke and 80mg of Oxy.

That’s a long-winded way of confirming what every stoner and the recreational user already knows – you can’t overdose on weed.

But not everyone equates “overdose” with “death.” Some medical professionals, not to mention those opposed to legalization, define an overdose as experiencing serious, non-fatal medical issues after overindulging. And that certainly can happen.

Here's how much marijuana it would take to kill you

Nearly half of Americans say they have tried marijuana at least once in their life.

With more people lighting up than ever (and nine states voting on the legalization of marijuana on Election Day), it's important to remember how many fatally overdose on the drug.

Zip. Zero. That's according to the Centers for Disease Control and Prevention which collects data on a range of other substances, both legal and illicit, and the Drug Enforcement Administration.

For comparison, opioids, which include prescription pain relievers and heroin, killed more than 28,000 Americans in 2014. Nearly 88,000 people die from alcohol-related causes every year, which makes alcohol the fourth leading preventable cause of the death in the US.

It's pretty impossible to ingest a lethal dose of marijuana.

David Schmader, author of "Weed: The User's Guide ," spoke with experts and crunched the numbers on how much bud it would take to kill someone.

"Even aspirin can kill you if you take too much, but a fatal dose of marijuana would require ingestion of fifteen hundred pounds in fifteen minutes — a physical impossibility for any human, even Snoop Dogg," Schmader writes in his book.

This handy diagram from "Weed: The User's Guide" might help:

One reason for this impossibility is the way the brain works. When a user ingests marijuana, chemicals in the plant ride the nervous system to the brain and latch onto molecules called cannabinoid receptors. Those little holding cells influence pleasure, memory, coordination, and cognition, among other functions, which is why getting high affects thinking and behavior.

Cannabinoid receptors are not found in the brainstem areas that control breathing. Thus, " lethal overdoses from c annabis and cannabinoids do not occur," The National Cancer Institute explains.

Marijuana isn't harmless, however. The psychoactive ingredient that gets users high, tetrahydrocannabinol, or THC, is a powerful intoxicant. Having physical abilities and judgments impaired can lead users to put themselves in unsafe situations.

And while there are no recorded cases of deaths from marijuana overdose, one bong rip too many can make users feel incredibly uncomfortable. Their heart starts to race, hands tremble, and anxiety strikes. There are things they can do to mitigate a "What I have done?" high.

In his book, Schmader recommends users tell themselves that they're in no real danger.

Drink some water to stay hydrated and eat a snack — preferably one that is ready-to-eat and does not require operating a stove — to boost your blood sugar . Call up a trusted friend, Schmader says, or Google search " Maureen Dowd Colorado" to feel less alone.

The Exhaustive List Of Everyone Who's Died Of A Marijuana Overdose

Friday is April 20, better known to many as 4/20, or “Weed Day.” People around the world are celebrating the unofficial marijuana holiday by gathering for rallies, smoke-outs, policy discussions and thousands of other weed-centric events.

It’s a day of blissful hypocrisy for millions of cannabis users in the U.S., who by and large are still expected to be somewhat covert about their fondness for the plant. The federal government maintains that marijuana is a dangerous illegal drug, with no accepted medicinal value and a high potential for abuse. Despite repeated calls for the reclassification of cannabis, it remains on the Drug Enforcement Administration’s list of Schedule I substances ― which also includes heroin, mescaline, LSD and a broad category of synthetic stimulants often referred to as “bath salts.”

The government’s message is clear: Marijuana and the psychoactive compound within it ― tetrahydrocannabinol, or THC ― poses a severe hazard to your health. To get a better sense of just how dangerous these substances are, The Huffington Post set out to compile a list of every person who has ever died solely as the result of a marijuana overdose.

There are no recorded instances of anyone dying from a fatal dose of marijuana alone.

Nothing has changed since the last time HuffPost highlighted this fact in 2013. And because the list was once again relatively easy to compile, we had time to find this GIF of a dog with the munchies. He did not overdose on marijuana ― though dogs can, so keep that in mind. He is also a good boy.

Fatally overdosing on marijuana in its most commonly ingested forms is seemingly impossible. In 1988, a DEA judge argued in favor of rescheduling marijuana in part because of its low harm profile. In his ruling, he wrote that a user would have to ingest somewhere between 20,000 to 40,000 times the amount of THC contained in a single joint to approach lethal toxicity.

“A smoker would theoretically have to consume nearly 1,500 pounds of marijuana within about fifteen minutes to induce a lethal response,” wrote Judge Francis Young.

Study results vary, but some suggest a lethal dose of marijuana may be even higher. Extrapolating from cannabis toxicity research on monkeys, a human would have to orally ingest more than 2.9 grams of THC per kilogram of body mass to be at risk of poisoning. At 88kg, the average American man would have to down more than an 9 ounces of 100 percent THC extract. That’s almost certainly not possible, but if it were, it might involve taking this “Dragon Ball” to the face.

“That’s far more than most people will consume throughout their entire lifetime,” said Jahan Marcu, chief science officer at Americans for Safe Access, an organization that advocates for cannabis as medicine.

The lack of death by marijuana poisoning doesn’t mean people haven’t been trying. Humans have been getting high since prehistoric times and for millennia, cannabis ― both in its flower and concentrated hashish forms ― has been one of our favorite intoxicants. People aren’t particularly prudent in their efforts to chemically alter their consciousness, so if it were possible to use a fatal dose of marijuana, it seems like someone would have done it. In fact, if some poor soul had managed to blaze up the close to a ton of herb necessary to achieve this morbid feat, you can be damn sure it would be the stuff of legend.

“People have tried to ingest as many plant cannabinoids as possible and there is no fatal overdose that has ever been documented in human beings,” Marcu said.

Opponents of marijuana might argue that just because it hasn’t happened before doesn’t mean it can’t happen in the future. They often point to growing concentrations of THC in modern pot plants as a cause for concern about increased harm. This ignores some important historical context, said Marcu.

“When you put those potency values on the scale of products that have been available and distributed and traded over millennia, they’re actually probably less potent than what someone would have gotten from a Moroccan hash trader a thousand years ago,” he said.

Although the era of “Reefer Madness” is not completely over ― just listen to some of the officials in the Trump administration ― it has proven increasingly difficult for the federal government to keep people scared about the supposed dangers of marijuana.

With tens of millions of Americans regularly reporting having used weed in the past year, it is the most commonly used illicit substance in the United States. Eight states and Washington, D.C., have now approved marijuana for recreational use, though sales remain banned in the nation’s capital. A total of 29 states have legalized marijuana for medical purposes .

And the relative harms of marijuana have begun to look less troubling as the nation’s attention has shifted to the ravages of highly addictive and often deadly opioids like heroin and fentanyl.

In 2006, a study in American Scientist compared the relative toxicity of marijuana to other commonly used substances, including some legal ones. It found that just 10 times the effective dose of alcohol and five times the effective dose of heroin could be enough to cause death in humans. Marijuana ranked among the least toxic drugs.

None of this is to say that using marijuana recreationally is as safe or as healthy as it would be to abstain completely. Although the science on even the most basic physiological effects of marijuana use remains incomplete and highly politicized, in rare cases it has been associated with disturbing adverse reactions. Studies have found that THC can exacerbate certain preexisting mental health conditions in some people, especially among younger users. Cannabis use has also been cited, albeit controversially, as a contributing factor in a handful of deaths of people with underlying cardiovascular conditions.

But scientists say the nature of these links is often inconclusive, inconsistent and highly dependent on the condition of the person using marijuana.

“There have been some associations seen with heavy cannabis use and development of possible psychotic behaviors, for example, but we don’t know if it’s a causal pattern,” said Sunil Kumar Aggarwal, a clinical instructor at the University of Washington’s school of medicine. “If it is, I can’t prove it.”

In states that have legalized cannabis, emergency rooms have reported an uptick in instances of cannabinoid hyperemesis syndrome, a mysterious illness that causes severe abdominal pain and vomiting. But these symptoms are not life-threatening and can be treated by stopping marijuana use, Aggarwal said.

Although a heavy dose of weed may not kill you, it’s certainly been known to make people feel uncomfortably high, leading to dysphoria, agitation, anxiety or panic. Those effects can seem like they last an eternity, but they’re reversible and tend to get better over a window of a few hours.

Sometimes, using marijuana in extreme excess can lead to poisoning or nonfatal overdose. But even then, the long-term damage pales in comparison to many other drugs. Aggarwal points out that taking too much of a common pain reliever like ibuprofen or acetaminophen can do serious harm to the liver, kidneys or stomach.

“We don’t see those kind of end organ damages with cannabinoids, especially natural-form extracts and that kind of thing,” he said.

It’s also important to remember that the conversation around marijuana use extends far beyond those who use it recreationally while celebrating on 4/20. Many people already rely on cannabis as a medicine. Even if the federal government won’t openly acknowledge its therapeutic effects, marijuana-based prescription pharmaceuticals like Marinol and cannabidiol treatments for epilepsy are proof that the plant’s benefits and harms are not as clear-cut as the DEA makes them out to be.

“These marijuana-derived products and purified forms of cannabis that have THC in them have been around for decades, and they’ve been prescribed to treat neurological disorders, not to cause them,” Marcu said. “If it was so bad for our nervous system and our brain, why is the first person we give it to someone who has multiple sclerosis, or HIV-AIDS, or neuropathy, or cancer, or a child with a disease?”

Clarification: This story has been updated to replace a reference to a study on the toxicity of marijuana for humans with another citation, as the origin of the initial citation was unclear. It also has been updated to amend a quote that misstated the effects of overdoses of acetaminophen and ibuprofen.

Scientists Identify the Lethal Dose of Kratom’s Active Ingredients

For thousands of people, the opioid-like plant kratom has been life-changing. But like many drugs, it’s not without potential risks. While patient interviews have revealed that kratom can offer some p…

F or thousands of people, the opioid-like plant kratom has been life-changing. But like many drugs, it’s not without potential risks. While patient interviews have revealed that kratom can offer some patients with chronic health conditions the relief that conventional opioids hadn’t and in some cases curbed dangerous opioid use, reality isn’t always so neat and clean. New research indicates that high enough doses of the two active molecules in kratom can cause death in mice, suggesting that it is possible to fatally overdose on the substance.

In a paper published October 31 in the journal Chemical Research in Toxicology, a team of researchers tested mitragynine and 7-hydroxymitragynine, the two main active molecules in kratom, on mice to establish their LD50 — a measure of lethal dosage. When researchers injected these chemicals into mice intravenously, they were lethal at around the same dosage as heroin.

“Mitragynine and 7-hydroxymitragynine, the two major alkaloids found in the pharmacologically active plant Kratom appear to have similar potency to each other and to heroin in Swiss Webster mice,” wrote the authors, led by Lauren Smith, a graduate student at The Scripps Research Institute. The team wrote that they found these results surprising, given that other research on kratom has shown a low potential for toxicity.

When scientists injected Swiss Webster mice with heroin, mitragynine, and 7-hydroxymitragynine, they found that similar dosages of all three molecules killed the mice.

Whereas the mice injected with heroin died from an average dose of 23.7 milligrams per kilogram of body weight (mg/kgbw), the mice injected with mitragynine died from 27.8 mg/kgbw, and those injected with 7-hydroxymitragynine died from 24.7 mg/kgbw. The researchers found 547.7 mg/kgbw to be the average lethal dose of mitragynine when it was taken orally. None of the mice died from oral doses of 7-hydroxymitragynine, but the mice given large oral doses of 7-hydroxymitragynine experienced seizures and depressed breathing.

These doses, fortunately, are out of the typical range of a kratom dosage. For instance, a 2015 study in Drug Design, Development and Therapy gave human subjects oral doses of kratom tea containing between 6.25 and 23 mg of mitragynine. For a person weighing 220 pounds, this translates to between 0.0625 and 0.23 milligrams per kilogram of body weight, over 100 times below the LD50 for mice. Of course, some kratom users push their limits, so it’s entirely possible some users get much higher doses. Nonetheless, there’s minimal evidence that they’re taking it intravenously.

The team also developed a urine test for mitragynine and 7-hydroxymitragynine that works in a similar way to other urine drug tests: by using an antibody to detect traces of drugs. In fact, this was their primary goal with the research, says Kim Janda, Ph.D., a professor of chemistry at Scripps and the corresponding author on the study.

He tells Inverse that the team wanted to develop “a simple diagnostic that could be used by law enforcement or health care professionals to monitor kratom’s use and potential abuse.” And indeed, it’s possible that a rapid lab test could be useful, as doctors and public health professionals are only starting to understand kratom’s impacts on human health.

This study comes at an inconvenient time for those who advocate for kratom to remain accessible. The US Drug Enforcement Administration is expected to rule on whether to make kratom illegal, though the timeframe for that decision is extremely unclear. On Friday, a DEA official told Inverse: “It could be next week, it could be the week thereafter, it could be the next month, it could be sometime next year.” Whatever the case may be, this research does not cast the plant in a flattering light.

Janda and his team weren’t out to demonize kratom, though. While some in the kratom advocacy community will inevitably dismiss this research, Janda emphasizes that the idea that his team is trying to help get the drug banned in the US couldn’t be further from the truth.

“We are trying to present an unbiased assessment of kratom and potentially give insights as why we are seeing more cases of kratom related overdoses,” he says. “Thus, we hypothesize that people are starting to IV kratom versus oral use.”

Earlier this year, the FDA released a report linking kratom to 44 deaths since 2009. The findings were far from conclusive, though, as many cases involved multiple other drugs, and none included full autopsy reports. It’s not clear whether people are actually taking kratom intravenously.

All this is to say that while some kratom users describe it as a miracle drug, it’s still a substance that scientists don’t understand all that well yet. It has other liabilities, too. For instance, a study published in August in the Journal of Psychoactive Drugs showed that people who use kratom regularly can experience psychological withdrawal symptoms.

While researchers are still exploring the potential harms and benefits of the plant-based drug, the case for kratom lies in the hands of federal regulators. And though the timeline is not clear, evidence from the FDA’s public stance on kratom suggests that the outlook is not good.

In the meantime, you can buy kratom from reputable vendors like Left Coast Kratom, both in store and online.


THC is an active ingredient in Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom in 2010 as a mouth spray for people with multiple sclerosis to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms. [20] [21] Nabiximols (as Sativex) is available as a prescription drug in Canada. [22] In 2021, Nabiximols was approved for medical use in Ukraine. [23]

Mechanism of action Edit

The actions of THC result from its partial agonist activity at the cannabinoid receptor CB1 (Ki = 10 nM [24] ), located mainly in the central nervous system, and the CB2 receptor (Ki = 24 nM [24] ), mainly expressed in cells of the immune system. [25] [26] The psychoactive effects of THC are primarily mediated by the activation of cannabinoid receptors, which result in a decrease in the concentration of the second messenger molecule cAMP through inhibition of adenylate cyclase. [27] The presence of these specialized cannabinoid receptors in the brain led researchers to the discovery of endocannabinoids, such as anandamide and 2-arachidonoyl glyceride (2-AG). [ citation needed ]

THC is a lipophilic molecule [28] and may bind non-specifically to a variety of entities in the brain and body, such as adipose tissue (fat). [29] [30] THC, as well as other cannabinoids that contain a phenol group, possess mild antioxidant activity sufficient to protect neurons against oxidative stress, such as that produced by glutamate-induced excitotoxicity. [25]

THC targets receptors in a manner far less selective than endocannabinoid molecules released during retrograde signaling, as the drug has a relatively low cannabinoid receptor affinity. THC is also limited in its efficacy compared to other cannabinoids due to its partial agonistic activity, as THC appears to result in greater downregulation of cannabinoid receptors than endocannabinoids. Furthermore, in populations of low cannabinoid receptor density, THC may even act to antagonize endogenous agonists that possess greater receptor efficacy. However while THC's pharmacodynamic tolerance may limit the maximal effects of certain drugs, evidence suggests that this tolerance mitigates undesirable effects, thus enhancing the drug's therapeutic window. [31]

Pharmacokinetics Edit

THC is metabolized mainly to 11-OH-THC by the body. This metabolite is still psychoactive and is further oxidized to 11-nor-9-carboxy-THC (THC-COOH). In animals, more than 100 metabolites could be identified, but 11-OH-THC and THC-COOH are the dominating metabolites. [32] Metabolism occurs mainly in the liver by cytochrome P450 enzymes CYP2C9, CYP2C19, CYP2D6, and CYP3A4. [33] [34] More than 55% of THC is excreted in the feces and ≈20% in the urine. The main metabolite in urine is the ester of glucuronic acid and 11-OH-THC and free THC-COOH. In the feces, mainly 11-OH-THC was detected. [35]

Discovery and structure identification Edit

Cannabidiol was isolated and identified from Cannabis sativa in 1940, [36] and THC was isolated and its structure elucidated by synthesis in 1964. [37] [38]

Solubility Edit

As with many aromatic terpenoids, THC has a very low solubility in water, but good solubility in lipids and most organic solvents, specifically hydrocarbons and alcohols. [8]

Total synthesis Edit

A total synthesis of the compound was reported in 1965 that procedure called for the intramolecular alkyl lithium attack on a starting carbonyl to form the fused rings, and a tosyl chloride mediated formation of the ether. [39] [ third-party source needed ]

Biosynthesis Edit

In the Cannabis plant, THC occurs mainly as tetrahydrocannabinolic acid (THCA, 2-COOH-THC, THC-COOH). Geranyl pyrophosphate and olivetolic acid react, catalysed by an enzyme to produce cannabigerolic acid, [40] which is cyclized by the enzyme THC acid synthase to give THCA. Over time, or when heated, THCA is decarboxylated, producing THC. The pathway for THCA biosynthesis is similar to that which produces the bitter acid humulone in hops. [41] [42]

No known lethal dose Edit

The median lethal dose of THC in humans is not known. A 1972 study gave up to 9000 mg/kg of THC to dogs and monkeys without any lethal effects. Some rats died within 72 hours after a dose of up to 3600 mg/kg. [43]

Detection in body fluids Edit

THC and its 11-OH-THC and THC-COOH metabolites can be detected and quantified in blood, urine, hair, oral fluid or sweat using a combination of immunoassay and chromatographic techniques as part of a drug use testing program or in a forensic investigation. [44] [45] [46]

Detection in breath Edit

Recreational use of cannabis is legal in many parts of North America, increasing the demand for THC monitoring methods in both personal and law enforcement uses. [47] Breath sampling as a noninvasive method is in development to detect THC, which is difficult to quantify in breath samples. [47] Scientists and industry are commercializing various types of breath analyzers to monitor THC in breath. [48]

THC was first isolated and elucidated in 1969 by Raphael Mechoulam and Yechiel Gaoni at the Weizmann Institute of Science in Israel. [37] [49] [50]

At its 33rd meeting, in 2003, the World Health Organization Expert Committee on Drug Dependence recommended transferring THC to Schedule IV of the Convention, citing its medical uses and low abuse and addiction potential. [51] In 2018 the federal farm bill was passed allowing any hemp derived product not exceeding 0.3% Δ-9 THC to be sold legally. Since the law counted only Δ-9 THC, Δ-8 THC was considered legal to sell under the farm bill and was sold online. After August 21st, 2020, all forms of THC were deemed illegal above 0.3% under the CSA (Controlled Substances Act), according to the DEA. The ruling is currently being debated [ by whom? ] and companies that formerly sold forms of THC are lobbying to keep other forms of THC (other than delta-9) legal for commerce. [52]

Comparisons with medical cannabis Edit

Female cannabis plants contain at least 113 cannabinoids, [53] including cannabidiol (CBD), thought to be the major anticonvulsant that helps people with multiple sclerosis [54] and cannabichromene (CBC), an anti-inflammatory which may contribute to the pain-killing effect of cannabis. [55]

Regulation in Canada Edit

As of October 2018 when recreational use of cannabis was legalized in Canada, some 220 dietary supplements and 19 veterinary health products containing not more than 10 parts per million of THC extract were approved with general health claims for treating minor conditions. [22]

The status of THC as an illegal drug in most countries imposes restrictions on research material supply and funding, such as in the United States where the National Institute on Drug Abuse and Drug Enforcement Administration continue to control the sole federally-legal source of cannabis for researchers. Despite an August 2016 announcement that licenses would be provided to growers for supplies of medical marijuana, no such licenses were ever issued, despite dozens of applications. [56] Although cannabis is legalized for medical uses in more than half of the states of the United States, no products have been approved for federal commerce by the Food and Drug Administration, a status that limits cultivation, manufacture, distribution, clinical research, and therapeutic applications. [57]

In April 2014, the American Academy of Neurology found evidence supporting the effectiveness of the cannabis extracts in treating certain symptoms of multiple sclerosis and pain, but there was insufficient evidence to determine effectiveness for treating several other neurological diseases. [58] A 2015 review confirmed that medical marijuana was effective for treating spasticity and chronic pain, but caused numerous short-lasting adverse events, such as dizziness. [59]


23 thoughts on &ldquo LD50 of Cannabis &rdquo

The only way to kill a rat with an LD50 test on marijuana is to get a big, big lump of resin and beat the poor animal to death with it ! I speak as a Pest Controller and a medical smoker, so I know abit about toxic substances and Rats!

Why do you smoke weed with the rats? Marihauna made my son commint double homicide. My older sister, bless her heart, died from smoking an entire bag of weed in a night. Marihauna is the devil’s invention. So you smoke your marihauna and get marihauna poisoning.

Marijuana does not affect the the heart or the respiratory system as they do not have cannabanoid receptors. It actually protects the brain by blocking access to new brain cells (thats why the short memory does not function, although this is just temporary).

So you are either confused with another drug or you are full of shit.

You are so full of bovine excrement we can smell it over the internet.

First, Marijuana did not MAKE your son do anything (he was a good boy, didn’t do nuttn, I know). He may have murdered someone FOR marijuana making the little angel a thief on top of a murderer. But weed didn’t MAKE him do it. Shitty culture may have encouraged it as well as other truly awful drugs.
Pot moves people to lovers not fighters. You may call bs but I was there so suck it. (for all legal purposes this is a work of fiction). I arrived at a bar for a little social hour, Friday evening, 9ish. Took a bar seat and ordered a drink. Just finished a first sip. There were about 12 people in the bar. This guy (linebacker beefcake high test in need of a little cut darker than walnut and just as hard) walked up and wanted to start something because I was in his seat. “get the f%&* out of my seat” “come on you pinche (I live close to Mexico) cracker, get the f%^* up” “come on, outside now” (Oh crap, I f’ed up. Went to the wrong bar and now Jack Tatum look alike is going to wad me up). I got up and at a light pace made my way to the patio as I thought that was better than fully outside. As I crossed the threshold to the patio I removed and lit the dube in my cap, sparked it and took a long drag as I turned and handed it to the bastard. It was a big cone and it took 10-15 minutes of puff puff pass, all in silence to ash it out. … … …Me: “You ready for a drink?” him: “yeah, just another minute” me: “okay”.

Second, there are four options that would cause your daughter to die from smoking “an entire bag of weed in a night”. First, the bag somehow got stuck over her head and being stupid or to ignorant to remove it (look at her brother and Concerned Parent, intelligence isn’t a theme in your family) was unable to find her way out and asphyxiated. Second, still related to her upbringing or education, she aspirated the bag and choked on it internally. Third, someone beat her to death for smoking their “ENTIRE BAG OF WEED IN A NIGHT”, least likely option. Fourth, If her bag contained 1,500 POUNDS and she smoked it by herself in 15 MINUTES she would have hit the LD50 dose where half of subjects would die. That’s not a bag, It is about 100 30 gallon rubber made containers of weed. While there are some that will smoke a 1/4 bag in a night (7 grams) they are usually wasting over half as many smokers mention a plateau where they just can’t get any higher no matter how much they smoke. The body only has so many receptors and once they are satruated you may be high longer but there is a point you peak out. Another “true story”, wax, oil, shatter, is refined THC, 70-90% THC, 5-10 times more pure than flower. A gram was packed into pipe, that’s equivalent to 5-10 grams of flower (a good sized bag). There was nothing to light it with so an industrial soldering iron at 650 F was resourced. One expected to smoke 20 or so drags out of the pipe over the next week. To my surprise 650 degrees on a large K tip iron vaporized the entire bowl nearly instantly in the first 2 seconds of the drag. That’s 14-20 joints in 2 seconds. Was it pleasant, no. Felt like someone had kicked a hornets nest in my chest and I barely made it the 4 steps from my bathroom to my bed. Did I die? No. Get sick? No. hang over, no. kill anyone, no. Rape, steal, cheat, abuse, no, no, no, no. Cough till I blew snot out of my nose for 5 minutes, yes.

Third, “Marihauna is the devil’s invention”. First I thought you were ignorant, now… wow, how do you get your pants on in the morning? Gen 1:12 The land produced vegetation: plants bearing seed according to their kinds and trees bearing fruit with seed in it according to their kinds. And God saw that it was good. Gen 1:29 Then God said, “I give you every seed-bearing plant on the face of the whole earth and every tree that has fruit with seed in it. They will be yours for food. Isaiah 18:4-5 4 For so the Lord said unto me, I will take my rest, and I will consider in my dwelling place like a clear heat upon herbs, and like a cloud of dew in the heat of harvest. 5 For afore the harvest, when the bud is perfect, and the sour grape is ripening in the flower, he shall both cut off the sprigs with pruning hooks, and take away and cut down the branches. Mat 15:11 The apostle Paul wrote, I know, and am persuaded by the Lord Jesus, that there is nothing unclean of itself: but to him that esteemeth anything to be unclean, to him it is unclean (it is unclean to you because you esteem to to be, but it is only to you that it is unclean. You can’t make it unclean to me because you don’t like it. I know, I like something you don’t like, I must be evil.

I mean, oh my god. 10s of thousands die from alcohol every year, hundreds die from aspirin, eating 10 raw potatoes is more dangerous than smoking a pounds worth of pot in a day. You might be stoned for a week but you wont get sick or die.

Posted by Twoyearsoldbutihopeyoureadthis | August 18, 2017, 1:42 am

Dear Concerned Parent. I am deeply sorry for your loss. nobody should experience anything like that. I am also a concerned parent – but I know for a fact that no one wakes up one day, smokes a bag of weed, gets a psychosis and decides to go on a murdering rampage. Every story has got their untold side stories – and even if he was your nice boy – perhaps you should have asked him, why he went out on a killing spree. I can only say weed doesnt kill people. – people kill people. If all drugs were legal and if the states who sell guns to people, earning money on selling guns – while fighting drugs in a so-called drug war with weapons they made tax money with while selling those guns to the drug king pins – would put all the tax money they would receive out of the legalisation of drugs and put it into educational systems where people would be wise enough to not try everything they may do, than we would not be having the problems, we are having right now. Most likely your kid might have known her limits and your boy might have known that guns do no good to people.

Hey, I’m really sorry to hear about your son. It must have hurt beyond what we could imagine, and I understand and respect your concern, and I can understand if you, or anyone else who can relate to you, want to place the blame on the drug they abused and ignore what I have to say. It is true that marijuana in a small portion of people, especially those who have a family history of schizophrenia, can cause psychosis which is associated with delusion which can possibly lead to violent behavior in distressed individuals. It is also possible that the marijuana, if it is street weed, had an adulterant in it, in particular one known as phencyclidine(pcp, angel’s dust, etc) which is a drug that’s high mimic’s psychosis and symptoms of schizophrenia, and is capable of causing far more severe symptoms than marijuana on its own. It could have also been used as a way to hype himself up before a murder that was already planned, as this is a well known use of some drugs.

It is well known that marijuana has very different symptoms in different people, and for some people they can be negative, in which case they can stop, and if they develop an addiction (which does happen in 10% of the population that uses it) they can seek help or taper off of it if they so please. However, a large portion of the population derives great benefit from it. It unfortunately doesn’t have many studies done on it, because it is considered a schedule 1 drug, however it has been shown in several to be effective in the treatment of ptsd, pain(including neuropathic), parkinsons, epilepsy, and many many other conditions. I know I can testify to the immense benefit it had on me.

I had severe depression for most of my life, and I wasn’t deriving any benefits from the SSRI/SNRIs I was taking. I was prescribed Lexapro for many years. I told my doctor that i don’t think I’m feeling any effect from it at all after several months went by, and he asked my parents if i looked happier, and they said yes, without knowing the harm it would have to me. And so I was set on this course for many years, and I started abusing ritalin, that was originally prescribed for my adhd. I thought that maybe this will make me feel something other than this stabbing ache of sadness I perpetually felt. I then added opiates to the mix. I had to quit them on my own several times without my parents knowing, which was a hell I don’t wish to experience again. My grades were plummeting, and I started a habit of physical self harm. I told no one about this and I tried to be as discreet about is as possible, because I knew my parents wouldn’t take it well and the attitude my parents instilled in me was to just push through the pain and do whatever it takes to get to my goal. I started using effexor with lexapro, and I derived no benefit, except this numb emotionless apathy which dominated all aspects of my life. I didn’t feel happy when I laughed or smiled. I felt more like a cue so I wouldn’t be viewed as a negative asshole who is never happy. I endured this hell, until I severely burned myself with sulfuric acid, hoping to quell a panic attack I was experiencing for over an hour, and it worked, at the cost of my body. I now have scars on my right foot and both my hands and arms.

Here is where I decided to try something new out of desperation. I did my research, and I thought that I could try marijuana as a last ditch effort. I never tried it before this moment. I’ve been using it for several months now, and my grades have gone up, and Im not addicted to anything anymore. I haven’t felt the need to harm myself. I don’t use it for very extended periods and take frequent breaks, but it arguably saved my life.

When people hear stories of marijuana making people go crazy and murder or steal, they don’t realize that they are doing a disservice to the many people who’s lives would be saved by it. Politicians will stick to a story like this to keep it illegal, since most of what we have about it is anecdotal evidence unfortunately. However, cases like this are very rare, unless its vehicular manslaughter if he was driving while high.

As for your sister, I’m really sorry that happened, but what most likely happened was that she was on another drug, like opiates, and smoked the marijuana with it, or the marijuana itself was laced with, for example, fentanyl, a synthetic opioid about 20-30 times as strong as heroin, and she didn’t know. Or, she suffered monoxide poisoning, although that would take a ridiculous amount of marijuana. There simply isn’t a way for marijuana to kill you at the normally used, and even excessive, doses.

I wish you the best of luck, and hope you’re doing better.

By the way, TWOYEARSOLBUTIHOPEYOUREADTHIS can go fuck himself. Miracle the mods let that one through.

What is the lethal dose of marijuana?

The report was commissioned by Richard Nixon in 1972. Thats almost 35 years of specialized breeding and cloning of plants, so I wouldn't be surprised if the THC is as high as you say. Even if the amount is 30 times higher, that still would be 1000 "joints" in 15 minutes to reach a "fatal" dose, keeping the odds of overdose, or anything even close to an overdose well outside the realm of the possible.

That said, youd still need to smoke a lotta grass to kill yourself.

The article wasn't talking about smoking it, but rather the consumption. And since most of the active ingredients are lost in the fire (bong, etc) youɽ have to smoke in the magnitudes of, I could guess, over 100+ pounds of the top grade stuff.

According to the Merck Index, 12th edition, the LD50, the lethal dose for 50% of rats tested by inhalation, is 42 mg/kg of body weight. That is the equivalent of a 165 lb (75 kg) man ingesting all of the THC in 21 one-gram cigarettes of high-potency (15% THC) cannabis buds at once, assuming no THC was lost through burning or exhalation. For oral consumption, the LD50 for rats is 1270 mg/kg and 730 mg/kg for males and females, respectively, equivalent to the THC in about a pound of 15% THC cannabis. Only with intravenous administration may such a level be even theoretically possible. [48] The ratio of cannabis required to saturate cannaboid receptors to the amount of cannabis required to have a fatal over dose is 1:40,000.

best quote from a legit scientist ever, "Simply stated, researchers have been unable to give animals enough marijuana to induce death."

I heard of someone who died when a 220 pound (100 Kilo) bale toppled off a truck in Indonesia.

In other words, alcohol is much more dangerous than pot.

Why is this still illegal? It doesn't even make sense on medical grounds, assuming the countless deaths from prohibition somehow make sense.

Because in the 1920's and 30's, black people liked to smoke it while they listened to the jazz. Mexicans liked it too. No joke - marijuana prohibition is an 80-year-old racist conspiracy. Eric Schlosser wrote about it.

it all depends on how many dealers you make angry.

As Someone who took part in the 1972 Rixard Nixon Study I can confirm that whilst the dose was not lethal I have only just come down.

Prohibtion is much more fatal and kills and destroys the lives of millions every year.

And the fact that Hemp biodiesel and Biomass ethanol is not grown by American Farmers on 6% of America's unused farmland (enough to fuel American current Petroleum Addiction) may well prove fatal to all life as we know it.

It has been demonstarted that plants could provide for the entire Petroleum economy in a Carbon Neutral fashion thus saving the planet and making the current war for oil unnecessary.

But that would benifit hardworking Americans instead of the easily monopoised fossil oil of the political elite.

Separate Church and State End Morality Laws.

Wake up America and expel the great Satan from the White House.

" Farming only 6% of continential U.S. acreage with biomass crops would provide all of America's gas and oil energy needs, ending dependence upon fossil fuels.

Manahan, Stanley E., Environmental Chemistry, 4th edition.

Hemp is Earth's number one biomass resource it is capable of producing 10 tons per acre in four months. Hemp is easy on the soil,* sheds its lush foliage throughout the season, adding mulch to the soil and helping retain moisture. Hemp is an ideal crop for the semi-arid West and open range land.


Marijuana does not pose a risk of lethal overdose. In other words, you can’t die from smoking too much weed.

Regardless, it’s certainly possible for users to consume too much marijuana at once. This is called overdosing or “greening out”.

Greening out is most likely among inexperienced users, or those who consume edibles. However, the effects are not permanent and symptoms eventually subside.

If you or a friend has consumed too much marijuana, keep hydrated, stay with people you know, and seek medical attention if things worsen.


  1. Escorant

    Also that we would do without your brilliant idea

  2. Tabbart

    absolutely agree

  3. Kelvyn

    I would like to talk with you on this issue.

  4. Sceapleigh

    Was it interesting?

Write a message